Yukari Manabe is a Professor in the Division of Infectious Diseases in the Department of Medicine with secondary appointments in the Bloomberg School of Public Health Department of International Health and the Department of Microbiology and Molecular Immunology. From 2007-2012, she was seconded to the Infectious Diseases Institute (IDI), Makerere University College of Health Sciences in Kampala, Uganda, where she was the Head of Research.
Dr. Manabe obtained her undergraduate degree from Yale University and her M.D. from Columbia University College of Physicians and Surgeons. After completing both her residency in Internal Medicine and fellowship in Infectious Diseases at Johns Hopkins Hospital, she joined the faculty in 1999.
Dr. Manabe has been doing operational and translational research in tuberculosis and HIV co-infection as well as evaluating TB and other point-of-care (POC) diagnostics in the IDI translational lab. Johns Hopkins has a long-standing collaboration with Makerere University and this will provide a unique opportunity to test POC STD diagnostics in a resource-limited setting/low income country where POC diagnostics are often the only ones available due to poor laboratory infrastructure. Dr. Manabe's role is to serve as the project's principal investigator and to oversee the project in the Ugandan resource-limited setting.
As part of the Center for Global Health, Dr. Manabe is interested in rapid diagnostics suitable for the resource-limited settings particularly in sub-Saharan Africa (SSA). She began her career working on the basic science aspects of tuberculosis (TB) immunopathogenesis in comparative animal models of infection, particularly latency, reactivation, and immune reconstitution inflammatory syndrome (IRIS) in the rabbit model within the Johns Hopkins Center for Tuberculosis Research. In 2007, she was seconded to the Infectious Diseases Institute (IDI) at Makerere College of Health Sciences as the Associate Medical Laboratory Director of the College of American Pathologists certified Makerere University-Johns Hopkins University Clinical Core Lab to study antiretroviral associated TB and IRIS. She then became the Head of Research at the IDI in 2008 until 2012 where she built research capacity and infrastructure for training Ugandan investigators. Her research has focused on accuracy testing of various rapid, point-of-care diagnostics for HIV and related infectious diseases of clinical importance in SSA. She is also interested in studying the impact of various diagnostic interventions on disease detection and patient outcomes.